Schizophrenia. Schizophrenia
Conditions
Interventions
Intervention 1: Intervention group: Risperidone 2 mg, three times/day + Fingolimod 0.5 mg everyday for 8 weeks. Intervention 2: Control group: Risperidone 2 mg, three times/day + Placebo tablet everyd
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Diagnosis of schizophrenia based on DSM-5 Minimum score of 60 based on PANSS Age range: 18-60 years old At least, 2 years have passed since the onset of the disorder
Exclusion criteria
Exclusion criteria: Diagnosis of another disorder in axis II Existence of a significant neurological or organic disease IQ less than 70 based on interviewer clinical suspicion Substance/drug dependence during the last 6 months (except nicotine and caffeine) Use of antipsychotics during past 1 week or long-term antipsychotics during past 1 month Receiving ECT during the last 2 weeks Abnormal endocrine activity Abnormal kidney and liver function History of thrombosis and emboli History of abnormal bleeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of schizophrenia. Timepoint: Baseline and weeks 4 and 8. Method of measurement: By Positive and Negative Syndrome Scale (PANSS). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShahin Akhondzadeh
Tehran University of Medical Sciences
Outcome results
None listed