Major Depressive Disorder. Major depressive disorder, single episode, severe without psychotic features
Conditions
Interventions
Intervention 1: Intervention group: Sertraline tablet (Sobhan co.) 100 mg per day + Cilostazol (Otsuka co.) tablet 100 mg per day for 8 weeks. Intervention 2: Control group: Sertraline tablet (Sobhan
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Based on DSM-5 diagnostic criteria, have major depression disorder Based on Hamilton depression scale, get the minimum score of 19 Age between 18 to 65 years old
Exclusion criteria
Exclusion criteria: Serious suicidal thoughts (The score of >2 in Hamilton depression scale, the suicidal tendencies section) Be psychosis Concomitant psychiatric disorders in axis 1 such as bipolar disorder, schizophrenia, alcohol and substance abuse disorders Concomitant psychiatric disorders in axis 2 such as personality disorder History of hypomania and mania History of Electroconvulsive therapy, two months prior to the trial Presence of Thyroid disorder Presence of cardiovascular disorder Diabetes Autoimmune disorder Cancer Presence of neurological disorders such as epilepsy, cerebral stroke, and dementia Kidney and liver disorders Pregnant or lactating women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of depression. Timepoint: Baseline and weeks 2, 4, and 8. Method of measurement: By Hamilton depression scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShahin Akhondzadeh
Tehran University of Medical Sciences
Outcome results
None listed