Postpartum depression. Postpartum mood disturbance
Conditions
Interventions
Intervention 1: Intervention group: Celecoxib capsule (Daroopakhsh, Tehran), 200 mg BID, oral (p.o.), for 8 weeks. Intervention 2: Control group: Placebo (BID), oral (p.o.), for 8 weeks.
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Age between 18 to 45 Having mild to moderate depression according to Hamilton Depression Rating Scale (HAM-D)
Exclusion criteria
Exclusion criteria: Having severe depression according to Hamilton Depression Rating Scale (HAM-D or HDRS) Addiction to drugs Addiction to alcohol Presence of Thyroid disease Receiving any antidepressant medications during past one month prior to the trial Receiving Electroconvulsive therapy during past two months prior to the trial Any other diagnosis according to axis-1, DSM-5 Having a risk of suicide based on doctor's clinical judgement or having a score of >2 in suicide item of Hamilton Depression Rating Scale (HAM-D or HDRS) Concomitant use of medications that increase the risk of gastrointestinal bleeding Presence of cardiovascular disease Pregnant and lactating women Risk of child murder
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of depression. Timepoint: Baseline and weeks 2, 4, 6, and 8. Method of measurement: By Hamilton Depression Rating Scale (HAM-D or HDRS). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShahin Akhondzadeh
Tehran University of Medical Sciences
Outcome results
None listed