Polycystic ovarian syndrome. Polycystic ovarian syndrome
Conditions
Interventions
Intervention 1: Intervention group: tablet sertralin 100 mg/day as intervention group for 6 weeks. Intervention 2: Control group: placebo as control group for 6 weeks.
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Women with PCOS diagnosed by the Rotterdam consensus criteria (Presence of 2 of the following 3 conditions: i. amenorrhea /oligomenorrhea ii. clinical or biochemical evidence of hyperandrogenism iii. Polycystic ovaries on ultrasound examination) Mild to moderate major depressive disorder based on DSM-5 criteria Score on Hamilton depression scale <18 Women aged 18-60 years Increased serum level of prolactin ( more than 20 ng per dl)
Exclusion criteria
Exclusion criteria: Psychotic symptoms Presence of any other mental disorder Receiving antidepressant treatment during the last 6 weeks Breastfeeding or pregnancy Thyroid diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of depression. Timepoint: Baseline and weeks 4 and 6 after beginning of treatment. Method of measurement: Hamiltion Depression Rating Scale 17-Item.;Serum level of prolactin. Timepoint: Baseline and weeks 4 and 6 after beginning of treatment. Method of measurement: ICMA. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShahin Akhondzadeh
Tehran University of Medical Sciences
Outcome results
None listed