Schizophrenia. Schizophrenia
Conditions
Interventions
Intervention 1: Intervention group: Tablet Risperidone (6 mg/day) combined with 100 mg/day Spironolactone as intervention group for 8 weeks. Intervention 2: Control group: Tablet Risperidone (6 mg/day
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Diagnosis of Schizophrenia based on DSM-5 criteria Age between 18-50 Chronic Schizophrenia- duration of the disorder more than 2 years Minimum score of 19 in negative sub score
Exclusion criteria
Exclusion criteria: Any serious medical or neurological problem IQ less than 70 Substance dependence during the last 6 months(except for nicotine and caffeine) Receiving ECT during the last 2 weeks Serum potassium more than 5 meq/L History of cardiosurgery Receiving oral antipsychotics during the last week or long-standing antipsychotic during the last month Meeting the criteria of major depressive disorder Suicidality Concurrent consumption of alcohol Pregnant or lactating women Receiving Pentoxifylline
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of schizophrenia. Timepoint: Baseline and weeks 2- 4- 8 after beginning of treatment. Method of measurement: by Positive and Negative Symptoms Scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Cognitive symptoms. Timepoint: Baseline and weeks 2- 4- 8 after beginning of treatment. Method of measurement: by MMSE. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShahin Akhondzadeh
Tehran University of Medical Sciences
Outcome results
None listed