Comparison of vortioxetine and sertraline for treatment of major depressive disorder in elderly patients

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20090117001556N118

Enrollment

Registered

2019-03-17

Start date

2019-04-05

Completion date

Unknown

Last updated

2020-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major Depressive Disorder. Major depressive disorder, single episode, moderate

Interventions

Intervention 1: Intervention group: vortioxetine 15 mg per day as intervention group for 6 weeks. Intervention 2: Control group: tablet sertralin 75 mg/day as control group for 6 weeks.

Eligibility

Sex/Gender

All

Age

60 Years to No maximum

Inclusion criteria

Inclusion criteria: Presence of Major Depressive Disorder based on DSM-5 criteria Baseline Hamilton Depression Rating Scale (HAM-D) (17-item) score of at least 19 Age at least 60 years old

Exclusion criteria

Exclusion criteria: Presence of psychosis Any other mental disorder Receiving psychotropic medications Receiving any antidepressants during past one month or ECT during past two months Hypothyroidism Cardiovascular disease

Design outcomes

Primary

Measure	Time frame
Severity of depression. Timepoint: Baseline and weeks 3 and 6. Method of measurement: By Hamiltion Depression Rating Scale 17-Item.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShahin Akhondzadeh

Tehran University of Medical Sciences

s.akhond@sina.tums.ac.ir+98 21 5541 2222

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026