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Evaluation of the effect of licorice as an adjunctive therapy for patients with Covid-19 admitted to the intensive care unit

Evaluation of the effect of licorice as an adjunct treatment for patients with Covid-19 admitted to the intensive care unit: A randomized, placebo-controlled, double-blind clinical trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20081208001497N10
Enrollment
60
Registered
2022-02-26
Start date
2022-03-05
Completion date
Unknown
Last updated
2022-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Covid-19. U07.1 COVID-19, virus identified

Interventions

Intervention 1: Intervention group: Eligible patients receive 760 mg / day (equivalent to two tablets) d-reGliss (Iran Darok) for five days. Patients will receive other routine Covid-19 treatments acc

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Covid-19 diagnosis based on PCR test Hospitalized in the intensive care unit and under mechanical ventilation

Exclusion criteria

Exclusion criteria: 1. Patients with high blood pressure (<90/140) Patients with congestive heart failure Patients with severe liver, kidney and thyroid disease Concomitant use of warfarin, SSRI, MAOI, diuretics, antiarrhythmic drugs Treatment with antiviral drugs one month before entering the study Allergy to licorice Pregnancy and lactation Dissatisfaction of the patient or his legal guardian Infected with Covid-19 for at least 20 days prior to enrollment

Design outcomes

Primary

MeasureTime frame
Average time out of intensive care unit. Timepoint: After discharge. Method of measurement: Number of hospitalization days.

Secondary

MeasureTime frame
Speed of recovery of Covid-19 clinical signs. Timepoint: The first and fourteenth day. Method of measurement: Percentage of improvement in symptoms.;Duration of hospitalization in the intensive care unit. Timepoint: After discharge or death. Method of measurement: Number of days of hospitalization.;Duration of mechanical ventilation. Timepoint: During hospitalization. Method of measurement: Number of days under mechanical ventilation.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSarah Mousavi

Esfahan University of Medical Sciences

s.mousavi@pharm.mui.ac.ir+98 31 3792 7072

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026