systemic sclerosis (scleroderma). Systemic sclerosis [scleroderma]
Conditions
Interventions
Intervention 1: Control group: ?Dominant hands of the patients. Normal saline (total volume 2.5 cc) with insulin syringe will be injected into the following sites: second-forth interdigital webs? base
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Scleroderma diagnosis based on the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR) criteria age>18 years Bilateral Raynaud's phenomenon with an intensity greater than 50 according to the Raynaud's condition score (RCS) questionnaire ?Dysfunction of the arm and shoulder and arm more than 50 according to the Quick Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire Pain intensity greater than 5 based on visual analog scale (VAS)
Exclusion criteria
Exclusion criteria: Active infection in any of the hands History of any botulinum toxin allergy History of upper extremity vascular surgery History of sympathectomy Pregnancy Breast feeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Raynaud's phenomenon symptoms. Timepoint: At the beginning of study and end of months 1 and 4. Method of measurement: Raynaud's phenomenon condition score Questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Ulcers of fingers. Timepoint: At the beginning and end of months 1 and 4. Method of measurement: Counting the number of ulcers and measuring the diameter of the ulcers.;Disabilities of the Arm, Shoulder and Hand. Timepoint: At the beginning of study and end of months 1 and 4. Method of measurement: Disabilities of the Arm, Shoulder and Hand Score(QuickDash). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammadhassan Jokar
Mashhad University of Medical Sciences
Outcome results
None listed