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Evaluation of seizures in infants with moderate and severe asphyxia

Evaluation of seizures in infants with moderate and severe asphyxia treated with intravenous acetaminophen

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20081021001378N14
Enrollment
60
Registered
2022-06-06
Start date
2021-11-22
Completion date
Unknown
Last updated
2022-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

moderate and severe asphyxia. Birth asphyxia

Interventions

Intervention 1: Intervention group: They will include infants who will be given an intravenous acetaminophen at a dose of 10 mg / kg for 3 days. Routine daily treatments are also performed. Interventi

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
1 Days to 30 Days

Inclusion criteria

Inclusion criteria: term newborn with 37 week gestational age more than 2 kg birth weight pH less than 7 base deficit more than 12 mmol/lit

Exclusion criteria

Exclusion criteria: preterm infants Anomalies less than 2 kg birth weight Genetic disorders Neuromacular disorders

Design outcomes

Primary

MeasureTime frame
The incidence of seizures. Timepoint: duration of hospitalization. Method of measurement: Based on clinical signs.;Time of start feeding. Timepoint: From the beginning of hospitalization to the end of hospitalization. Method of measurement: Based on abdominal examination, the presence of intestinal sounds and the absence of vomiting.;Feeding tolerance. Timepoint: From the beginning of feeding to the end of hospitalization. Method of measurement: Abdominal examination, clinical observation of the infant and evaluation for vomiting or malnutrition.

Secondary

MeasureTime frame
Evaluation of heart disorder at the end of acetaminophen treatment. Timepoint: duration of hospitalization. Method of measurement: Based on clinical signs and then if there are echocardiographic symptoms.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMhadese Khakpour

Mashhad University of Medical Sciences

khakpormh981@mums.ac.ir38521121

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026