COVID-19. COVID-19 Disease
Conditions
Interventions
Intervention 1: Intervention group: In addition to the standard treatment regimen for COVID-19, the trans sodium crocetinate spray with a nebulizer as an oral spray twice a day will be given for 1 wee
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Patients with clinical diagnosis for COVID-19 disease Patients with acute respiratory distress syndrome (ARDS) PF ratio (the ratio of arterial oxygen partial pressure to fractional inspired oxygen) <200 Patients not having kidney, liver and heart dysfunction according to clinical and laboratory findings
Exclusion criteria
Exclusion criteria: Allergic reactions to saffron Pregnancy and breast-feeding, Multi organ dysfunction disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frequency of patients mortality. Timepoint: during 7 days hospitalization. Method of measurement: counting the number. | — |
Secondary
| Measure | Time frame |
|---|---|
| Days under ventilation. Timepoint: during 7 days hospitalization. Method of measurement: time.;Hospitalization days in ICU. Timepoint: during 7 days hospitalization. Method of measurement: time.;Getting multi organ dysfunction. Timepoint: During 7 days hospitalization. Method of measurement: Clinical and laboratory evaluation.;Improving PF ration. Timepoint: daily during 7 days hospitalization. Method of measurement: ratio calculated from PaO2/FiO2.;Improving Sofa (The sequential organ failure assessment ) score. Timepoint: the first day and during 7 days hospitalization. Method of measurement: According to clinical and laboratory evaluation. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHossein Hosseinzadeh
Mashhad University of Medical Sciences
Outcome results
None listed