Covid-19. COVID-19 Disease
Conditions
Interventions
Intervention 1: Intervention group: In addition to the standard treatment regimen for COVID-19, the trans sodium crocetinate 1 mg/kg/day will be given i.v. for 1 weeks. Intervention 2: Control group:
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients with clinical diagnosis for Covid-19 disease, Patients with acute respiratory distress syndrome (ARDS), Patients not having kidney, liver and heart dysfunction according to clinical and laboratory findings PF ratio (the ratio of arterial oxygen partial pressure to fractional inspired oxygen) <300 ,
Exclusion criteria
Exclusion criteria: Allergic reactions to saffron Pregnancy or breast-feeding Multi organ dysfunction disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patients' mortality rate. Timepoint: During 7 days hospitalization. Method of measurement: Meedical Reports. | — |
Secondary
| Measure | Time frame |
|---|---|
| Days under ventilation. Timepoint: During 7 days hospitalization. Method of measurement: Meedical Reports.;Hospitalization days in ICU. Timepoint: During 7 days hospitalization. Method of measurement: Medical Report.;Getting multi organ dysfunction. Timepoint: During 7 days hospitalization. Method of measurement: Clinical and laboratory evaluation.;Improving PF ration. Timepoint: daily during 7 days hospitalization. Method of measurement: ratio calculated from PaO2/FiO2.;Improving Sofa (The sequential organ failure assessment ) score. Timepoint: the first day and during 7 days hospitalization. Method of measurement: According to clinical and laboratory evaluation. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAmirhoushang Mohammadpour
Mashhad University of Medical Sciences
Outcome results
None listed