Comparison effect of Ziziphi jujube and Melissa Officinale extract with Escitalopram on the treatment of depression

Comparison effect of Ziziphi jujube and Melissa Officinale extract with Escitalopram on the treatment of adulthood depression

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20081011001323N28

Enrollment

100

Registered

2021-10-22

Start date

2021-08-21

Completion date

Unknown

Last updated

2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

moderate depression. Major depressive disorder, single episode, moderate

Interventions

Intervention 1: Intervention group: Combined alcoholic extract of Ziziphi jujube and Melissa officinale with a dose of 600 milligrams per day prepared in form of capsule and prescribed with 10 milligr

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Adult patients(older than 18 years old) Suffering from mild to moderate depression Having informed consent form

Exclusion criteria

Exclusion criteria: Suffering from bipolar disorder Patients with acute psychosis Patients with cardiovascular disease or hepatic function impairment Patients with any history of allergy to chemical or herbal drugs Pregnant women

Design outcomes

Primary

Measure	Time frame
Improvement of depression symptoms. Timepoint: Before start of treatment,3 and 6 weeks later. Method of measurement: According to Hamilton questionnaire.	—

Secondary

Measure	Time frame
Evaluating drug reactions. Timepoint: During treatment and 3 and 6 weeks next. Method of measurement: According to patient reports and physician examination.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSaied Razmeh

Yasouj University of Medical Sciences

srazmeh@yahoo.com+98 74 3322 1812

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026