Effect of oral contraceptives on levels of adipokines, and adiposity indices in women with polycystic ovary syndrome

A randomized clinical trial to compare the effectiveness of oral contraceptives containing levonorgestrel, desogestrel, cyproterone acetate, and drospirenone on levels of adipokines, and adiposity indices in women with polycystic ovary syndrome.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20080929001281N3

Enrollment

Registered

2020-03-26

Start date

2019-05-24

Completion date

Unknown

Last updated

2020-04-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Reproductive health..

Interventions

Intervention 1: Intervention group 1: Oral contraceptives containing Ethinyl estradiol (EE) 30 µg + levonorgestrel 0.15 mg (daily for 21 days and then 7 days withdrawal) made by Iran Hormone company,

Eligibility

Sex/Gender

Female

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Existence of diagnostic criteria for polycystic ovary syndrome based on Androgen Excess and PCOS Society (AES) Age range: 18 to 45 years

Exclusion criteria

Exclusion criteria: Pregnancy Use of hormonal; anti-androgen or insulin sensitizer drugs for at least 3 months before the study Detection of severe hypertension; chronic disease; recent surgery or diagnosis of cancer Smoking Obesity Appearing the serious side effects such as thrombosis

Design outcomes

Primary

Measure	Time frame
Serum levels of adiponectin. Timepoint: baseline, 6th month. Method of measurement: Assessment of this parameter will be done using Human ELISA kites.;Serum levels of leptin. Timepoint: baseline, 6th month. Method of measurement: Assessment of this parameter will be done using Human ELISA kites.;Serum levels of resistin. Timepoint: baseline, 6th month. Method of measurement: Assessment of this parameter will be done using Human ELISA kites.	—

Measure

Time frame

Serum levels of adiponectin. Timepoint: baseline, 6th month. Method of measurement: Assessment of this parameter will be done using Human ELISA kites.;Serum levels of leptin. Timepoint: baseline, 6th month. Method of measurement: Assessment of this parameter will be done using Human ELISA kites.;Serum levels of resistin. Timepoint: baseline, 6th month. Method of measurement: Assessment of this parameter will be done using Human ELISA kites.

—

Secondary

Measure	Time frame
Blood pressure. Timepoint: Baseline, 6th month. Method of measurement: Sphygmomanometer.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMina Amiri

Shahid Beheshti University of Medical Sciences

mina_amiri_p@yahoo.com+98 21 2243 2500

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 26, 2026