Overweight and Obesity. Obesity, unspecified
Conditions
Interventions
Intervention 1: Intervention group: Participants in this group will take a 5 mg melatonin tablet one hour before going to bed at night with enough water for 8 weeks. Intervention 2: Control group: Par
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
19 Years to 49 Years
Inclusion criteria
Inclusion criteria: Apparently healthy women volunteers Literate 19-49 years BMI=25-34.9 kg/m2 Having high hedonic eating intensity Unwillingness to diet Desire to use drugs or supplements to lose weight
Exclusion criteria
Exclusion criteria: Postmenopausal, pregnant or lactating women Recent weight loss or participation in weight loss programs Suffering from binge eating Current smokers Recent history of taking supplements affecting appetite (in the last 3 months) Women who, according to themselves, are suffering from substance abuse, alcohol addiction, certain diseases such as cancer, heart disease and diabetes Women who, according to themselves, have hypothyroidism and use medicine for this purpose Women who, according to themselves, use drugs that affect appetite, such as antidepressants, steroids, and contraceptives Having night shifts Having severe insomnia or thyroid disorders Using drugs that interfere with melatonin (anti-hypertensive drugs, anticonvulsant drugs, beta blockers, anticoagulant drugs, sedatives, antidepressants, oral contraceptive pill, corticosteroids) Melatonin supplementation intolerance during the study Using less than 90% melatonin supplements or placebo
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma level of acyl ghrelin. Timepoint: Before starting and at the end of the study. Method of measurement: ELISA. | — |
Secondary
| Measure | Time frame |
|---|---|
| Plasma level of 2-arachidonylglycerol. Timepoint: Before starting and at the end of the study. Method of measurement: ELISA.;Hedonic eating score. Timepoint: The first phase of the study and at the end of the study. Method of measurement: Power of food scale.;Total energy intake. Timepoint: Before the start of the study, after 4 weeks, and at the end of the study. Method of measurement: 3-day food recall.;Energy intake from macronutrients. Timepoint: Before the start of the study, after 4 weeks, and at the end of the study. Method of measurement: 3-day food recall.;Weight. Timepoint: Before the start of the study, after 4 weeks, and at the end of the study. Method of measurement: Scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMalihe Karamizadeh
Tabriz University of Medical Sciences
Outcome results
None listed