Sepsis, unspecified organism. Sepsis, unspecified organism
Conditions
Interventions
Intervention 1: Intervention group: Oral sachet, contains 300mg vitamin C and 10mg Zinc (produced by Bonyan-Salamat-Kasra company), 7 sachets, every 12 hours, PO for 10 days. Intervention 2: Control g
Sponsors
Bagheiat-allah University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Having suspected or proven infection; Increasing 2 points or more of SOFA score compared to the baseline; The patient or his/her guardian has informed and free written consent to participate in the study;
Exclusion criteria
Exclusion criteria: Multi organ dysfunction; Glasgow Coma Score (GCS) less than 4; The patient needs emergency dialysis due to severe acidosis or end stage renal disease; Pregnancy; Breastfeeding; Being NPO for any reasons; Having kidney stones as his/her medical history; Having hypersensitivity reactions with the intervention in the past;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 30-days Mortality rate;. Timepoint: Daily, till 30 days. Method of measurement: Vital signs assessment. | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of ICU stay. Timepoint: Daily, until the discharge or death. Method of measurement: Medical record assessment.;Length of hospital stay. Timepoint: Daily, until the discharge or death. Method of measurement: Medical record assessment.;Vasopressor dose. Timepoint: Day 1, 5 and 10. Method of measurement: Check the medication list.;SOFA score changes. Timepoint: Day 1, 5 and 10. Method of measurement: Sequential Organ Failure Assessment(SOFA) score. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactParisa Kianpour
Tehran University of Medical Sciences
Outcome results
None listed