The effect of licorice and ginger herbal composition on controlling patients' pain symptoms after knee joint replacement surgery

Evaluation of the efficacy and safety of Glycyrrhiza glabra and zingiber officinale in controlling pain symptoms in patients after Total Knee Arthroplasty(TKA)

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20080901001165N62

Enrollment

100

Registered

2020-07-02

Start date

2020-09-21

Completion date

Unknown

Last updated

2020-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis, Total knee arthroplasty (TKA), Pain after surgery. Unilateral primary osteoarthritis, unspecified knee

Interventions

Intervention 1: Intervention group:They will receive a diclofenac treatment (75 mg daily) one hour after meals daily. Furthermore, the herbal combination of licorice and ginger ( capsules 500 mg) will

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients are candidates for complete knee replacement after surgery and hospital discharge

Exclusion criteria

Exclusion criteria: Inflammatory underlying disease such as rheumatoid arthritis Drug addiction smoking

Design outcomes

Primary

Measure	Time frame
Comparison of the effect of different doses of licorice and ginger herbal composition in one group and diclofenac drug in the second group. Timepoint: Before the intervention, and 8, 12 and 24 hours after consuming the herbal combination, licorice and ginger, every 12 hours to 8 weeks. Method of measurement: The pain VAS is a unidimensional measure of pain intensity.	—

Secondary

Measure	Time frame
Post-intervention Quality of life score. Timepoint: Up to 28 weeks after the intervention. Method of measurement: It will be measured according to the Cop Corn questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAlireza Rahimnia

Bagheiat-allah University of Medical Sciences

dr.rahimnia@bmsu.ac.ir+98 21 8755 5131

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026