COVID-19. Covid-19
Conditions
Interventions
Intervention 1: Intervention group: Plasmapheresis 3-5 session (based on clinical improvement), In addition to Amp. Methylprednisolone (500 mg day1, 250 mg day 2 and day3, IV) and routine treatment a
Sponsors
Bagheiat-allah University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Confirmed diagnosis of COVID-19, with either lung CT-Scan result, which is typical for COVID-19 pulmonary involvement,or RT-PCR confirmation. The patient/Legal guardian has written consciously and freely consent to participate in the study; The patient has moderate to severe Corona-Virus associated pneumonia; In the first 48 hours of hospitalization, the patient did not show an improving trend; In the first 48 hours after his/her inclusion into this study, there is no possibility of discharge from the patient's hospital;
Exclusion criteria
Exclusion criteria: Multi organ failure; Pregnancy; Lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Need to receive ICU service (occurrence of shock, resistant hypoxemia despite receiving oxygen via reservoir oxygen mask, GCS score drops below 12). Timepoint: The patient is monitored every 6 hours, but the results are recorded daily in the checklist. Method of measurement: Physical assessment. | — |
Secondary
| Measure | Time frame |
|---|---|
| Mortality rate. Timepoint: 30 days after including the study. Method of measurement: Physical assessment.;Length of hospitalization. Timepoint: The first day and the end of hospitalization. Method of measurement: The hospital record review.;Radiologic response. Timepoint: At the admission, before the discharge. Method of measurement: lung CT-SCAN.;Laboratory changes. Timepoint: Daily. Method of measurement: Blood sample, laboratory analysis.;Fever. Timepoint: Daily. Method of measurement: Thermometer.;Respiratory distress. Timepoint: Daily. Method of measurement: Clinical assessment.;Oxygen saturation without receiving oxygen supplement. Timepoint: It will be measured every 6 hours, but will be recorded daily. Method of measurement: Pulse-oxymetery device. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Rezapour
Bagheiat-allah University of Medical Sciences
Outcome results
None listed