Acute respiratory distress syndrome (ARDS). Acute respiratory distress syndrome
Conditions
Interventions
Intervention 1: First Intervention group: Wharton's jelly derived mesenchymal stem cells. Intervention 2: Second Intervention group: Amniotic membrane derived mesenchymal stem cells. Intervention 3: T
Sponsors
Bagheiat-allah University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Signed informed consent voluntarily Confirmed ARDS SOFA score between 2-3 point PaO2/FIO2 = 300 mmHg Mild to Moderate pneumonia/ stay in the ICU 50% in 24-48 hours
Exclusion criteria
Exclusion criteria: Co-Infection of HIV, tuberculosis, influenza virus, adenovirus and other respiratory infection virus Liver or kidney SOFA score of more than 3 points; combined with other organ failure Patients with malignant tumor Pregnant or lactating women Uncontrolled underling diseases Pulmonary obstructive pneumonia, severe pulmonary interstitial fibrosis, allergic alveolitis, and other known viral pneumonia or bacterial pneumonia In vitro life support (ECMO, ECCO2R, RRT)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Numbers of Patients Occurred Any Unexpected Severe Adverse Events (Including All-cause Deaths). Timepoint: Before Intervention, Day 0 (First Intervention) till Day 7, Day 14, Day 28, 3 Moths, 6 Months and 12 months after intervention. Method of measurement: Fill Common Terminology Criteria for Adverse Events (CTCAE) Form. | — |
Secondary
| Measure | Time frame |
|---|---|
| PaO2/FiO2 assessment. Timepoint: Before Intervention, Day 0 (First Intervention) till Day 7, Day 14, Day 28, 3 Moths, 6 Months and 12 months after intervention. Method of measurement: Ventilator. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHoda Madani
Iranian academic center for education culture and research
Outcome results
None listed