Psoriasis. Psoriasis
Conditions
Interventions
Intervention 1: Intervention First group: Single intra-dermal injection of 50 µg of exosomes derived from adipose tissue mesenchymal cells per cm2 of plaque into 0.5 ml of normal saline and follow up
Sponsors
Skin and Stem cell Research Center of Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Chronic plaque psoriasis for at least 6 months plaque Mild to severity of moderate (grade 1-3) PASI 3-12 No response to standard treatments No incidence of new lesion or increase in size of previous lesions during past 3 months
Exclusion criteria
Exclusion criteria: Other types of psoriasis include pustular, erythrodermic, gotate, and drug induced Immunosuppressive drugs over the past 4 weeks or topical medications other than moisturizing lotions in the 2 past weeks Severe underlying disease (including liver, kidney and heart failure), increased liver enzymes more than 3 times normal and creatinine more than 2 high and uncontrolled blood pressure Pregnancy or lactation diabetes mellitus Hepatitis B, C or HIV Patients with immunodeficiency Patients with malignancy Disabling disease Systemic or injection site infection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain. Timepoint: intervention start date up to 3 months. Method of measurement: Pain intensity scale.;Redness severity. Timepoint: intervention start date up to 3 months. Method of measurement: Physical examination. | — |
Secondary
| Measure | Time frame |
|---|---|
| Lesion severity (grade 1-3). Timepoint: Before intervention, every week up to 1 month, and every month up to 3 months. Method of measurement: evaluator assessment. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohamad Ali Mohseni Meybodi
Skin and Stem Cell Research Center, Tehran University of Medical sciences
Outcome results
None listed