Osteoarthritis. Osteoarthritis, unspecified site
Conditions
Interventions
Intervention 1: Intervention group: Patients will orally take one 500 mg capsule of the herbal mixture (containing frankincense, ginger, and wild olive) produced by the Medicinal Plants Research Cente
Sponsors
Iranian academic center for education culture and research
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients with osteoarthritis visit to Baqiyatallah Hospital in Tehran Male or female patients aged 40 to 80 years According to the criteria of the American College of Rheumatology, Knees osteoarthritis grade 1 or 2
Exclusion criteria
Exclusion criteria: Arthroscopy, Surgery, or Injection to the target knee joint within the past 6 months History of knee replacement Any serious systemic disease (such as secondary infections and cardiovascular, liver, and kidney diseases) Any other chronic inflammatory disease Any history of alcohol and drug abuse Fibromyalgia and other debilitating diseases affecting the knees Blood clotting disorders, and or use of anticoagulants such as warfarin and heparin Use of antiplatelet drugs such as aspirin, and thrombolytic drugs Pregnant women, women who are planning to have children, and women who are breastfeeding are not included in the plan.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Joint pain. Timepoint: Before intervention and end of intervention after 2 months. Method of measurement: The Visual Analogue Scale Questionnaire.;Joint stiffness. Timepoint: Before intervention and end of intervention after 2 months. Method of measurement: The Western Ontario and McMaster Universities Arthritis Index Questionnaire.;Physical activity. Timepoint: Before intervention and end of intervention after 2 months. Method of measurement: The Western Ontario and McMaster Universities Arthritis Index Questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Dose of acetaminophen used. Timepoint: Before intervention and end of intervention after 2 months. Method of measurement: Daily recording of the acetaminophen dose used by the patient.;Blood urea nitrogen. Timepoint: Before intervention and end of intervention after 2 months. Method of measurement: The level of urea nitrogen in the blood is measured by an autoanalyzer in the laboratory.;Creatinine. Timepoint: Before intervention and end of intervention after 2 months. Method of measurement: The level of creatinine in the blood is measured by an autoanalyzer in the laboratory.;Aspartate aminotransferase. Timepoint: Before intervention and end of intervention after 2 months. Method of measurement: The level of aspartate aminotransferase in the blood is measured by an autoanalyzer in the laboratory.;Alanine aminotransferase. Timepoint: Before intervention and end of intervention after 2 months. Method of measurement: The level of alanine aminotransferase in the blood is measured by an autoanalyzer in the laboratory.;Blood cell count. Timepoint: Before intervention and end of intervention after 2 months. Method of measurement: Blood cell counts are measured in the laboratory using a cell counter.;Severity of arthritis. Timepoint: Before intervention and end of intervention after 2 months. Method of measurement: The Western Ontario and McMaster Universities Arthritis Index Questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFallah Huseini Hasan
Iranian academic center for education culture and research
Outcome results
None listed