Osteoarthritis. Osteoarthritis, unspecified site
Conditions
Interventions
Intervention 1: Intervention group: Nigella sativa oil emulsion
Patients taking a tablespoon of nigella sativa oil emulsion three times a day after food (5 ml nigella sativa oil daily) for one month. Intervention 2: Placebo group: Placebo emulsion
Patients taking a tablespoon of placebo emulsion three times a day after food ( total 5 ml mineral oil taking per day) for one month.
Sponsors
Iranian academic center for education culture and research
Eligibility
Sex/Gender
All
Age
50 Years to 70 Years
Inclusion criteria
Inclusion criteria: Male or female patients with knee osteoarthritis 1 or 2 intensity according to physical examination and knee joint radiography Age 50 to 70 years Exacerbation of the disease at a rate of at least 2 units of sub-total pain score after discontinuation of analgesic drugs which was used at least 3 days a week during the last month A minimum of 9 points out of 20 for pain, joint stiffness and physical activity of the patient according to the criteria of Western Ontario and McMaster Universities pain subscale index after discontinuing analgesic drug medications
Exclusion criteria
Exclusion criteria: Patients with secondary osteoarthritis due to a known disease Patients with history of arthroscopy, surgery, knee replacement and injection to the knee joint during the last 6 months Any serious systemic disease and other chronic inflammatory disease Patients receiving steroid anti-inflammatory drugs, muscle relaxant, antidepressants, glucosamine, chondroitin, tramadol, topical analgesic agents Like the capsaicin Alcohol consuming and drug abuse patients Patients who refuse to stop analgesic drugs No flares after discontinuation of analgesic drugs that using at least 3 days a week during the last months Breast-feeding, pregnant women and who intend to have children
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of arthritis. Timepoint: Before and end of intervention after 1 month. Method of measurement: The Western Ontario and McMaster Universities Arthritis Index Questionnaire.;Extent of joint pain. Timepoint: Before and end of intervention after 1 month. Method of measurement: The Western Ontario and McMaster Universities Arthritis Index Questionnaire.;Extent of joint stiffness. Timepoint: Before and end of intervention after 1 month. Method of measurement: The Western Ontario and McMaster Universities Arthritis Index Questionnaire.;Extent of physical function. Timepoint: Before and end of intervention after 1 month. Method of measurement: The Western Ontario and McMaster Universities Arthritis Index Questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Dose of acetaminophen used. Timepoint: Before intervention and after 1 month at end of the intervention. Method of measurement: Daily recording of the acetaminophen dose used by the patient.;Pain intensity. Timepoint: Before and end of the study and after one month. Method of measurement: Visual Analog Scale questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFallah Huseini Hasan
Iranian academic center for education culture and research
Outcome results
None listed