Comparison of mixed double-embryo transfer and blastocyst double-embryo transfer in frozen-thawed embryo transfer cycles

To compare the clinical outcomes following simultaneous double-embryo transfer of cleavage and blastocyst stages and transfer of blastocyst double-embryo transfer in frozen-thawed embryo transfer cycles

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20080831001141N36

Enrollment

200

Registered

2021-01-06

Start date

2019-05-14

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility. Female infertility

Interventions

Intervention 1: Intervention group: Double-embryos will be transferred simultaneously at the cleavage and blastocyst stages. Intervention 2: Control group: Blastocyst double-embryos will be transferr

Eligibility

Sex/Gender

Female

Age

20 Years to 39 Years

Inclusion criteria

Inclusion criteria: Women with a history of one failure in implantation in cycle of ART in which at least two good quality embryos were transferred in each cycle. Women with age less than 40 years old Women with BMI less than 30 kg/m2 Women with at least four good quality frozen embryos

Exclusion criteria

Exclusion criteria: Previous uterine surgery which disturb endometrial function Women with uterine factor infertility Women with recurrent abortion Women with severe male factor infertility Women with poor ovarian response Women with ovarian endometrioma Women taking aspirin and heparin with the treatment cycle Women with myoma more than 5 cm Women have myoma with pressure effect on endometrium Women with known genetic disorders Women with history of more than 3 IVF failures Women whose embryos failed to reach the blastocyst stage after thawing (at least 2 embryos) Women with poor quality thawed embryos

Design outcomes

Primary

Measure	Time frame
Clinical pregnancy. Timepoint: 4-6 weeks after embryo transfer. Method of measurement: The observation of gestational sac on ultrasound examination.	—

Secondary

Measure	Time frame
Implantation. Timepoint: 4-6 weeks after embryos transfer. Method of measurement: The observation of gestational sac on ultrasound examination.;Miscarriage. Timepoint: 6-20 weeks after embryo transfer. Method of measurement: The spontaneous loss of a clinical pregnancy that occurs before 20 completed weeks of gestational age.;Ongoing pregnancy. Timepoint: Pregnancy after 20 weeks of gestation. Method of measurement: Vaginal sonography.	—

Measure

Time frame

Implantation. Timepoint: 4-6 weeks after embryos transfer. Method of measurement: The observation of gestational sac on ultrasound examination.;Miscarriage. Timepoint: 6-20 weeks after embryo transfer. Method of measurement: The spontaneous loss of a clinical pregnancy that occurs before 20 completed weeks of gestational age.;Ongoing pregnancy. Timepoint: Pregnancy after 20 weeks of gestation. Method of measurement: Vaginal sonography.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactTahereh Madani

Royan Institute

tmadani@royaninstitute.org+98 21 2356 2645

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 7, 2026