Poor ovarian response. Complications of attempted introduction of fertilized ovum following in vitro fertilization
Conditions
Interventions
Intervention 1: Intervention group: ?Duostim: The follicular stimulation will be started with a fixed dose of 150 IU of rFSH and HMG 75 IU for 4 days. Daily administration of a GnRH antagonist will be
Sponsors
Royan Institute
Eligibility
Sex/Gender
Female
Age
35 Years to 45 Years
Inclusion criteria
Inclusion criteria: Age =35 years Antimullerian hormone (AMH) <1.2 ng/ml and/or antral follicular count=5 follicles =4 oocyte retrieved from previous ART cycle 18.5<BMI<30
Exclusion criteria
Exclusion criteria: Endometriosis (stage III and IV) Myoma with a compression effect Uterine anomalies (Unicorn, Didelphis,etc,….) Male factor infertility with azoospermia, severe oligospermia and oligoasthenospermia, TESE/PESA
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MII (Metaphase II) oocyte numbers and quality. Timepoint: Immediately after oocyte puncture. Method of measurement: Embryologist report. | — |
Secondary
| Measure | Time frame |
|---|---|
| Cleaved embryo numbers. Timepoint: 2-3 days after oocyte puncture and sperm insemination. Method of measurement: Embryologist report.;Blastocyst numbers. Timepoint: 5 days after oocyte puncture and sperm insemination. Method of measurement: Embryologist report.;Clinical pregnancy rate. Timepoint: 4-6 weeks after embryo transfer. Method of measurement: Vaginal ultrasound.;Fertilization rate. Timepoint: 2-5 days after sperm insemination. Method of measurement: Embryologist report. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMehri Mashayekhi
Royan Institute
Outcome results
None listed