Polycystic ovarian syndrome. Polycystic ovarian syndrome
Conditions
Interventions
Intervention 1: Intervention group: Patients will receive rFSH (with or without HMG) at a dose of 150 to 225 IU/day and MPA 10 mg/day from day 3 of menstruation. Intervention 2: Control group: Patient
Sponsors
Royan Institute
Eligibility
Sex/Gender
Female
Age
18 Years to 39 Years
Inclusion criteria
Inclusion criteria: The major criteria for diagnosis of PCOS are oligo and/or anovulation, clinical or biochemical signs of hyperandrogenism and polycystic ovaries; these criteria are in accordance with the revised 2003 Rotterdam criteria for PCOS Age between 18 to 39 years Body mass Index (BMI) less than 30 kg/m2
Exclusion criteria
Exclusion criteria: Clinically significant systemic disease such as renal failure Endometriosis grade 3 or higher Received hormonal treatments in the previous 3 months Any contraindications to ovarian stimulation Sever male factor (TESE-PESA)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fertilization rate. Timepoint: 16-18 hours after sperm insemination or injection. Method of measurement: The ratio between the number of zygotes with two pronucleus and the injected oocytes. | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of retrieved oocytes including GV, MI, MII. Timepoint: Immediately after oocyte puncture. Method of measurement: GV: Germinal vesicle present in the ooplasm; MI: No visible GV in the ooplasm and no first polar body in the perivitelline space; MII: Small perivitelline space containing a single unfragmented first polar body.;Number of MII oocytes. Timepoint: Immediately after oocyte puncture. Method of measurement: Observation of oocytes that were mature at the time of oocyte collection.;OHSS occurrence. Timepoint: From puncture to subsequent mensturation. Method of measurement: Classification system according to the Navot scheme, including mild, moderate and severe forms.;Premature LH surge. Timepoint: During ovarian stimulation until the day of triggering. Method of measurement: Serum LH level of equally or more than 10 mIU or an increase of more than 2.5 times above the basal level.;Clinical pregnancy. Timepoint: 4-6 weeks after embryo transfer. Method of measurement: The observation of gestational sac on ultrasound examination two-three weeks after positive serum ßhCG. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactParisa Mostafaei
Royan Institute
Outcome results
None listed