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Comparison of the effect of haloperidol versus dexmedetomidine in the prevention of delirium after cardiac surgery

Comparison of the effect of haloperidol versus dexmedetomidine in the prevention of delirium after cardiac surgery

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20080830001127N9
Enrollment
180
Registered
2022-12-04
Start date
2023-01-21
Completion date
Unknown
Last updated
2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Delirium. Other delirium

Interventions

Intervention 1: Intervention group: As soon as the patient is admitted to the ICU, the loading dose and then the infusion of dexmedetomidine will be started. Intervention 2: Intervention group: As soo

Sponsors

Tabriz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: All adult patients 18 up to 75 years old , candidates of elective cardiac surgery with cardiopulmonary bypass

Exclusion criteria

Exclusion criteria: History of previous CVA without full recovery for 5 years - emergency procedures - death in ICU Emergency surgeries Death in ICU Patients under 18 years old and over 75 years old History of neurological and mental diseases or taking antipsychotic drugs Not using cardiopulmonary bypass Allergy to haloperidol or dexmedetomidine Dementia QTc interval greater than 500 ms or complete heart block History of malignant neuroleptic syndrome Bradycardia Liver and kidney diseases

Design outcomes

Primary

MeasureTime frame
Delirium. Timepoint: during ICU stay. Method of measurement: CAM–ICU measurement tool.

Secondary

MeasureTime frame
Duration of need to mechanical ventilation. Timepoint: During hospitalization in ICU. Method of measurement: Counting the number of hours of mechanical ventilation in the ICU.;Length of stay in ICU. Timepoint: Reviewing the patient ICU records. Method of measurement: Counting the number of days of ICU stay.;Mortality. Timepoint: During hospitalization in ICU. Method of measurement: Reviewing the patient ICU records.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactEissa Bilehjani

Tabriz University of Medical Sciences

isasdavod@gmail.com+98 41 3337 3950

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026