Diabetes mellitus in pregnancy. Unspecified diabetes mellitus in pregnancy, childbirth and the puerperium
Conditions
Interventions
Intervention 1: Intervention group: Administration of oral metformin 500 mg tablets (Tehran Chemie Pharmaceutical co.) once a day until the end of pregnancy. Intervention 2: Control group: Subcutaneou
Sponsors
Rasht University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: Pregnant women with singletons Having gestational diabetes after 26 weeks
Exclusion criteria
Exclusion criteria: Having overt diabetes Having fasting sugar more than 120 mg/dL Having blood sugar one hour after a meal above 200 mg/dL Having chronic diseases of the digestive system Having a contraindication use for metformin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood sugar. Timepoint: Fasting before the intervention and one hour after the intervention weekly until the end of pregnancy. Method of measurement: Glucometer. | — |
Secondary
| Measure | Time frame |
|---|---|
| Maternal hypoglycemic episodes. Timepoint: Fasting before the intervention and one hour after the intervention weekly until the end of pregnancy. Method of measurement: Glucometer.;Blood pressure disorders in pregnancy. Timepoint: Monthly visit after the start of the intervention. Method of measurement: Sphygmomanometer.;Preterm delivery. Timepoint: Postpartum. Method of measurement: Delivery earlier than 37 weeks of pregnancy.;Intrauterine fetal death. Timepoint: Weekly visit after the start of the intervention. Method of measurement: Absence of fetal heartbeat in ultrasound.;Polyhydramnios. Timepoint: Weekly visit after the start of the intervention. Method of measurement: Sonography.;Macrosomia. Timepoint: Postpartum. Method of measurement: scales.;Nneonatal hypoglycemia. Timepoint: After birth. Method of measurement: Bleeding of the heel.;Shoulder dystocia. Timepoint: During childbirth. Method of measurement: Observation.;Respiratory distress syndrome. Timepoint: Weekly visit after the start of the intervention. Method of measurement: Neonatal specialist report.;Need for Neonatal Intensive Care Unit. Timepoint: After birth. Method of measurement: Neonatal specialist report.;Metformin side effects. Timepoint: Immediately after intervention and weekly follow-up. Method of measurement: Patient report. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSeyedeh Hajar Sharami
Rasht University of Medical Sciences
Outcome results
None listed