Evaluation of transplantation of autologous cultured fibroblast on amniotic membrane for treatment of epidermolysis bullosa patients with mitten hand deformity

Safety and efficacy of transplantation of autologous cultured fibroblast on amniotic membrane for treatment of epidermolysis bullosa patients with mitten hand deformity after hand surgery phase 1

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT20080728001031N28

Enrollment

Registered

2021-02-01

Start date

2010-04-19

Completion date

Unknown

Last updated

2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epidermolysis Bullosa patients with mitten hand deformity. Epidermolysis bullosa dystrophica

Interventions

Intervention group: Transplantation of autologous cultured Fibroblast on amniotic membrane for treatment of epidermolysis bullosa patients with mitten hand deformity.

Eligibility

Sex/Gender

All

Age

2 Years to 30 Years

Inclusion criteria

Inclusion criteria: Epidermolysis Bullosa patients with mitten hand deformity Patients with 2 to 30 years old

Exclusion criteria

Exclusion criteria: History of other systemic disease History of other cell therapy method Infection in donor or recipient Site Positive Lab tests for contagious viral diseases Pregnancy or lactating

Design outcomes

Primary

Measure	Time frame
Safety assessment of autologous transplantation of cultured fibroblast on amniotic membrane for healing of mitten hands. Timepoint: Patients' dressings were changed every 7 days until the wound was completely healed. Then the visits were done in 3, 6, 12 months and then annually. Method of measurement: Physical examination.;Histological evaluation of autologous transplantation of cultured fibroblast on amniotic membrane for healing of mitten hands. Timepoint: 6 month after transplantation. Method of measurement: Biopsy.	—

Measure

Time frame

Safety assessment of autologous transplantation of cultured fibroblast on amniotic membrane for healing of mitten hands. Timepoint: Patients' dressings were changed every 7 days until the wound was completely healed. Then the visits were done in 3, 6, 12 months and then annually. Method of measurement: Physical examination.;Histological evaluation of autologous transplantation of cultured fibroblast on amniotic membrane for healing of mitten hands. Timepoint: 6 month after transplantation. Method of measurement: Biopsy.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactHoda Maadani

Royan Institute

hoda62_m@yahoo.com+98 21 2251 8388

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026