Effects of topical flutamid on melasma lesions

Clinical trial of topical flutamid on melasma compared with topical hydroquinon

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT138905114310N4

Enrollment

Registered

2010-08-24

Start date

2008-09-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Melasma.

Interventions

Intervention 1: Topical flutamid + antisolar cream for 4 months. Intervention 2: Topical hydroquinon+antisolar cream for 4 months.

Treatment - Drugs

Topical hydroquinon+antisolar cream for 4 months

Topical flutamid + antisolar cream for 4 months

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Inclusion criteria: 1- Females with melasma 2- Consent to participate Exclusion criteria: 1- Pregnancy 2- Breastfeeding 3- Taking OCP, spironolactone or phenytoein 4- Receiving antipigmentation therapy during the last four months

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Reduction of pigmentation. Timepoint: 30 day. Method of measurement: Photography-Mexameter-Clinical examination-Patient satisfaction.	—

Secondary

Measure	Time frame
Side effects of drugs. Timepoint: One months. Method of measurement: Clinical examination.;Patient satisfaction. Timepoint: 3 months. Method of measurement: Check list.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Mohsen Arzanlou

Deputy of research , Ardebil medical university

m.arzanlou@arums.ac.ir+98 45 1551 0054

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026