Acute Myocardial Infarction. Acute myocardial infarction
Conditions
Interventions
Intervention 1: Intervention: NAC 600 mg BD PO for 3 days. Intervention 2: Control: Placebo BD PO for 3 days.
Prevention
Intervention: NAC 600 mg BD PO for 3 days
Control: Placebo BD PO for 3 days
Sponsors
Tehran University of Medical sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria: ST-elevation AMI diagnosed by the following criteria: (1) typical chest pain lasting >30 minutes, (2) 1-mm ST elevation in 2 contiguous limb leads or 2-mm ST elevation in 2 contiguous chest leads, and (3) increase in creatine kinase or in troponin T level to 2 times the upper limit of normal. Exclusion criteria: previous AMI or HF, AF or valve disease, and history of neoplastic, renal, liver, or thyroid disease, acute or chronic infections or autoimmune diseases, under treatment with anti-inflammatory drugs, or underwent surgical procedures in the preceding 3 months, unwillingness for entering in the study
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MMP-9 as early cardiac remodeling biomarker. Timepoint: 24 and 72 hours after administration of NAC. Method of measurement: Elisa.;Nt-pro-BNP as early cardiac remodeling biomarker. Timepoint: 24 and 72 hours after administration of NAC. Method of measurement: Elisa.;MMP-2 as early cardiac remodeling biomarker. Timepoint: 24 and 72 hours after administration of NAC. Method of measurement: Elisa. | — |
Countries
Iran (Islamic Republic of)
Outcome results
None listed