Evaluating the effectiveness of ketamine on muscle pain (myalgia), headache and restlessness (agitation) after electroconvulsive therapy in patients with major depression disorder.

Survey the effectiveness of ketamine on myalgia, headache and agitation in Major Depression patients after electroconvulsive therapy.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT138904221766N4

Enrollment

Registered

2011-11-19

Start date

2011-10-16

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Electroconvoulsive therapy induced myalgia. Myalgia

Interventions

Intervention 1: Control group: In this group 2 ml normal saline (placebo) will be injected before any other drugs in zero time. Intervention 2: Study group: In this group 30 Mg Ketamine that had been

Prevention

Control group: In this group 2 ml normal saline (placebo) will be injected before any other drugs in zero time.

Study group: In this group 30 Mg Ketamine that had been diluted in 2 ml normal saline will be injected before any other drugs in zero time.

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Major depression based on DSM 4 criteria, physical condition in accordance with ASA Class 1 or 2, ability and capacity to sign informed consent sheet. Exclusion criteria: history of major systemic disease, history of neuromuscular disease, history of myalgia.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Myalgia. Timepoint: At 6, 12, 24 and 48 hours after ECT. Method of measurement: Myalgia graded as follow: absence of myalgia = no; stiffness or muscle pain did not need treatment = mild; muscle pain or stiffness reported spontaneously by the patient, and required therapy = moderate; very severe discomfort = severe.;Headache. Timepoint: In the first 24 hours after ECT. Method of measurement: Visual Analoge Scale.;Agitation. Timepoint: In the recovery period. Method of measurement: 1. Yes: motor restlessness, severe motor movement, and besides, un-aimed try to leave the bed, wanting to get up from bed, high loud crying, pulling catheters, confusion and poor response to verbal commands) 2 . No: not mentioned in any of the above scenarios.	—

Measure

Time frame

Myalgia. Timepoint: At 6, 12, 24 and 48 hours after ECT. Method of measurement: Myalgia graded as follow: absence of myalgia = no; stiffness or muscle pain did not need treatment = mild; muscle pain or stiffness reported spontaneously by the patient, and required therapy = moderate; very severe discomfort = severe.;Headache. Timepoint: In the first 24 hours after ECT. Method of measurement: Visual Analoge Scale.;Agitation. Timepoint: In the recovery period. Method of measurement: 1. Yes: motor restlessness, severe motor movement, and besides, un-aimed try to leave the bed, wanting to get up from bed, high loud crying, pulling catheters, confusion and poor response to verbal commands) 2 . No: not mentioned in any of the above scenarios.

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Secondary

Measure	Time frame
Seizure duration. Timepoint: After induction of ECT. Method of measurement: Second.;Mean arteial blood preasure. Timepoint: Befor induction of anesthesia ,after induction of anesthesia ,and after termination of seizure. Method of measurement: Milimeter of Hg.;Heart Rate. Timepoint: Befor induction of anesthesia , after induction of anesthesia ,and after termination of seizure. Method of measurement: Beat /minute.	—

Measure

Time frame

Seizure duration. Timepoint: After induction of ECT. Method of measurement: Second.;Mean arteial blood preasure. Timepoint: Befor induction of anesthesia ,after induction of anesthesia ,and after termination of seizure. Method of measurement: Milimeter of Hg.;Heart Rate. Timepoint: Befor induction of anesthesia , after induction of anesthesia ,and after termination of seizure. Method of measurement: Beat /minute.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactZohreh Ziaee

Faculty of Medicine

dr.ziaee24@yahoo.com+98 87 1666 4664

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026