Chronic bronchitis. Chronic bronchitis: obstructive
Conditions
Interventions
Intervention 1: Intervention group:40 mg atorvastatin daily for 3 months. Intervention 2: Control group: one placebo tablet daily for 3 months.
Treatment - Drugs
Intervention group:40 mg atorvastatin daily for 3 months
Control group: one placebo tablet daily for 3 months
Sponsors
shiraz University Of medical Science
Eligibility
Sex/Gender
Male
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: exposure to mustard gas during the Iran-Iraq war and have suffered from chronic bronchitis (history of chronic cough and sputum daily for 3 months during recent 2 years) Exclusion criteria: Using statin in the last 3 months of study starting time; exacerbation of symptoms in the past 4 weeks; connective tissue disease; sarcoidosis; eosinophilic granuloma; pneumoconiosis; lymphoma; carcinomatous; smokers
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TNF alpha level. Timepoint: before intervention - 3 month after intervention. Method of measurement: ELISA test is performed.;Interleukin 6 level. Timepoint: before intervention - 3 month after intervention. Method of measurement: ELISA test is performed.;Added at 2015-08-05: Procalcitonin. Timepoint: Added at 2015-08-05: At the beginning of the intervention and 3 months after intervention. Method of measurement: Added at 2015-08-05: ELISA. | — |
Secondary
| Measure | Time frame |
|---|---|
| Withe blood cell count. Timepoint: before intervention - 3 month after intervention. Method of measurement: Complete Blood Count.;Added at 2015-08-05: hs-CRP. Timepoint: Added at 2015-08-05: At the beginning the intervention and 3 months after intervention. Method of measurement: Added at 2015-08-05: Immunoassay. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr seyed Masoom Masoompour
Shiraz University of Medical Sciences
Outcome results
None listed