Polycystic ovarian syndrome. Polycystic ovarian syndrome
Conditions
Interventions
Intervention 1: intervantion group: 50000 IU vitaminD3 every 20 days for 60 days. Intervention 2: control group: placebo every 20 days for 60 days.
Treatment - Drugs
Placebo
Sponsors
Research Vice-chancellor of Tabriz University of Medical Sciences and Nutrition Research Center of T
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: diagnosis of PCOS based on Rotterdam criteria (presence of two of the three following characteristics: 1. oligomemorreha /amenorrhea, 2. chemical or clinical finding of hyperandrogenism and 3. polycystic appearance of ovary), voluntary consent for participation in the study, age of 16-40 years, gender: female. Exclusion criteria: Other common causes of hyperandrogenemia and/or anovulation; hyperprolactinoma, congenital adrenal hyperplasia, Cushing syndrome, and virilizing ovarian or adrenal tumors, diabetes mellitus and heart, kidney and liver dysfunction, using vitamin D or Calcium supplement, metformin or insulin sensitizing drugs, corticosteroids, anticonvulsants during last 2 month or during the study, Smoking, alcohol abuse, breast feeding and pregnancy.
Exclusion criteria
Exclusion criteria:
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Antropometric indicators (BMI). Timepoint: 60 days. Method of measurement: Body weight without shoes with calibrated scale, Standing height without shoes are measuredl. BMI was calculated with this equation: W(kg) /H(m)2.;Dietary regime. Timepoint: 60 days. Method of measurement: 3 days 24h dietaty racall. | — |
Primary
| Measure | Time frame |
|---|---|
| Improvement of gelycemic parameters. Timepoint: 60 days. Method of measurement: serum level of blood suger and fasting Insulin.;Lipid profile and hs-CRP. Timepoint: 60 days. Method of measurement: Serum level of HDL, LDL, Total Cholesterol, TG, ApoA1, hs-CRP.;Serum level of alkaline phosphatase, calcium and phosphorus. Timepoint: 60 days. Method of measurement: serum level. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactBahram Pourghassem
Health and Nutrition Faculty, Tabriz university of medical sciences
Outcome results
None listed