Cutaneous leishmaniasis. Cutaneous leishmaniasis (any type)
Conditions
Interventions
Intervention 1: Treatment of Nitroglycerin patch(the pharmacy of Nour and Ali Asghar hospital in Isfahan) 1 time every day covered nearly 2-3 inch of lesion + interlesional injection of placebo (injec
Treatment - Other
Treatment of Nitroglycerin patch(the pharmacy of Nour and Ali Asghar hospital in Isfahan) 1 time every day covered nearly 2-3 inch of lesion + interlesional injection of placebo (injection of distille
Interlesional injection of Glucantime(Meglusan) from Avenue de Scheut company in Belgica, 1 time every week, nearly 15-30 mg until whitening of base of the ulcer + treatment of placebo patch(the pharm
Sponsors
Vice chancellor for research, Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria: 1- Patients with a diagnosis of acute zoonotic cutaneous leishmaniasis has been proven parasitology by direct smear 2- Patients must be 18-50 age 3- Lesion diameter is not greater than 3 cm 4- The number of lesion is one 5- Lesions are not on the face near the eyes, joints, cartilage, on the nose and ears 6- Less than three months passed from diseases times. Exclusion Criteria: 1- The status of women in pregnancy and lactation 2- The risk of presence or incidence of sporotrichoid or Satellite lesions 3- Patients with a history of hepatitis, heart and kidney disorder 4- People who are taking immunosuppressive medications (over the last 6 months) 5- history of local or systemic treatment against leishmaniasis in the last 3 months 6- Patients with a history of heart attack or high blood pressure 7- Liver disease 8- Patients with anemia 9- Patients with a history of surgery for head and brain hemorrhage 10- Patients with blood pressure medications, antidepressants, or drugs used for angina.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lesion area. Timepoint: 8, 12, 20 weeks after end of treatment. Method of measurement: Pictzar software.;Induration. Timepoint: 1, 2, 3, 4, 7, 8, 12, 16, 20 weeks after end of treatment. Method of measurement: Physical examination.;Improvement rate. Timepoint: 1, 2, 3, 4, 7, 8 weeks during treatment and 12, 16, 20 weeks after end of treatment. Method of measurement: Observation and examination. | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects. Timepoint: 3 months after treatment. Method of measurement: Observation and examination. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactLeila Shirani Bidabadi
Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Ir
Outcome results
None listed