Effect of Vitamin C and Vitamin E Supplementation on Postprandial Oxidative Stress, Inflammatory Markers, Lipid Profile , Insulin and Blood Glucose Level of Type 2 Diabetic Patients

Effect of Vitamin C and Vitamin E Supplementation on Postprandial Oxidative Stress, Inflammatory Markers, Lipid Profile, Insulin and Blood Glucose Level of Type 2 Diabetic Patients

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT138904073236N1

Enrollment

Registered

2010-10-15

Start date

2009-04-04

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diabetes mellitus. Non-insulin-dependent diabetes mellitus

Interventions

Intervention 1: placebo intake for 6 weeks. Intervention 2: vitamin C intake 1000mg/pday for 6 weeks. Intervention 3: vitamin E intake

400IU/pday for 6 weeks.

Placebo

Treatment - Drugs

placebo intake for 6 weeks

vitamin C intake 1000mg/pday for 6 weeks

vitamin E intake

400IU/pday for 6 weeks

Eligibility

Sex/Gender

All

Age

25 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1- having diabetes 2- normal blood pressur 3- age between 25 to 65 4- having diabetes for maximum 15 years 5- nonsmoker, nonalcoholic 6- not taking vitamin and/or mineral supplement, insulin therapy, lipid lowering, hormone replacement therapy, diuretics or ß-blockers and aspirin 7- no history or clinical evidence of overt vascular disease, acute or chronic inflammatory disease and kidney stones 8- no history of radiation therapy

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Blood glucose fasting and postprandial. Timepoint: 4 times, before and 6 weeks after intervention, fasting and postprandial. Method of measurement: Auto analyser.;Insulin Fasting and postprandial. Timepoint: 4 times,before and after intervation, fasting and postprandial. Method of measurement: Radio Immune Assay.	—

Secondary

Measure	Time frame
Lipid profile. Timepoint: before and 6 weeks after intervention, fasting and postprandial. Method of measurement: auto analyser.;Malondialdehyde. Timepoint: before and 6 weeks after intervention. Method of measurement: spectrophotometery.;High sensetive C-Reactive Protein. Timepoint: before and 6 weeks after intervention, fasting and postprandial. Method of measurement: ELIZA.;Interlukin-6. Timepoint: before and 6 weeks after intervention, fasting and postprandial. Method of measurement: Radio Immune Assay.	—

Measure

Time frame

Lipid profile. Timepoint: before and 6 weeks after intervention, fasting and postprandial. Method of measurement: auto analyser.;Malondialdehyde. Timepoint: before and 6 weeks after intervention. Method of measurement: spectrophotometery.;High sensetive C-Reactive Protein. Timepoint: before and 6 weeks after intervention, fasting and postprandial. Method of measurement: ELIZA.;Interlukin-6. Timepoint: before and 6 weeks after intervention, fasting and postprandial. Method of measurement: Radio Immune Assay.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNajmeh Hejazi

School of Health and Nutrition, Shiraz University of Medical Sciences

n20hejazi@yahoo.com+98 71 1720 6963

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026