advanced periodontitis disease. Chronic Periodontitis
Conditions
Interventions
Intervention 1: Doxycycline one 40mg capsule per day plus intensive scaling and root planing. Intervention 2: One placebo capsule per day plus intensive scaling and root planing.
Treatment - Drugs
Placebo
Doxycycline one 40mg capsule per day plus intensive scaling and root planing
One placebo capsule per day plus intensive scaling and root planing
Sponsors
Vice-Chancellor for Research, Guilan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Age 40 to 70 years , Being systemically healthy with no history of Arthritis, GI disorders, skin diseases, bronchitis, Diabetes Mellitus, pregnancy or breast feeding, Body mass index between 20-27, Existence of at least 20 standing teeth without untreated periapical lesions, and at least 15% of sites with more than or equal to 5 mm of clinical attachment loss and evidence of bone loss in at least two quadrants. Exclusion criteria: Being under treatment with drugs such as: anticoagulants, steroids, anti-inflammatory drugs, immunosuppressant drugs within past 6 months, any periodontal treatment within past three months, heavy smokers
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum inflammatory mediator: TNF-a. Timepoint: Baseline and one month after the intervention. Method of measurement: Laboratory test: ELIZA.;Serum inflammatory mediator: IL-6. Timepoint: Baseline and one month after the intervention. Method of measurement: Laboratory test: ELIZA.;Serum cholesterol levels. Timepoint: Baseline and one month after the intervention. Method of measurement: Routine laboratory tests.;Serum level of LDL. Timepoint: Baseline and one month after the intervention. Method of measurement: Routine laboratory tests.;Serum level of HLDL. Timepoint: Baseline and one month after the intervention. Method of measurement: Routine laboratory tests.;Serum triglyceride levels. Timepoint: Baseline and one month after the intervention. Method of measurement: Routine laboratory tests. | — |
Secondary
| Measure | Time frame |
|---|---|
| Periodontal parameter: Probing Pocket Depth. Timepoint: Baseline and one month after the intervention. Method of measurement: Calibrated periodontal probe.;Periodontal parameter: Clinical Attachment Level. Timepoint: Baseline and one month after the intervention. Method of measurement: Calibrated periodontal probe.;Periodontal parameter: Bleeding on probing. Timepoint: Baseline and one month after the intervention. Method of measurement: Bleeding points index ( Lenox & Kopczyk).;Dental Plaque. Timepoint: Baseline and one month after the intervention. Method of measurement: Oleary plaque index. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNastaran Mirfarhadi
Department of Periodontology, Dental Research Center, School of Dentistry, Guilan University of Medi
Outcome results
None listed