Investigating the effect of Casein Phosphopeptide -Amorphous Calcium Phosphate with Fluoride on caries prevention

Investigating the effect of pH changes in orthodontic patients using Casein Phosphopeptide -Amorphous Calcium Phosphate with Fluoride paste

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT138903244185N1

Enrollment

Registered

2011-07-12

Start date

2010-08-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Caries limited to enamel. White spots (Initial caries)

Interventions

Intervention 1: As a crossover study, patients in the first group receive the medication - MI paste plus - containing casein phosphopeptide - amorphous calcium phosphate and Fluoride. A pea-sized amo

Treatment - Drugs

As a crossover study, patients in the first group receive the medication - MI paste plus - containing casein phosphopeptide - amorphous calcium phosphate and Fluoride. A pea-sized amount of the paste

As a crossover study, patients in the second group receive the placebo paste first. The placebo is also a paste but devoid of any active ingredient. A pea-sized amount of the paste is applied to the t

Eligibility

Sex/Gender

All

Age

12 Years to No maximum

Inclusion criteria

Inclusion criteria: Inclusion criteria:Patients receiving fixed orthodontic treatment and over 12 years of age. Between 3 and 12 months of their orthodontic treatment should have commenced. Exclusion criteria: Taking medications; systemic diseases; pregnancy; loss/missing of first permanent molars; using mouthwashes.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Salivary pH. Timepoint: Before and after each paste use. A total of 4 measures with one month intervals. Method of measurement: pH test strips.;Plaque pH. Timepoint: Before and after each paste use. A total of 4 measures with one month intervals. Method of measurement: pH test strips.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHaleh Heshmat DMD,MS

School of Dentistry, Tehran Azad University

h_heshmat@yahoo.com+98 21 8808 5500

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026