Atherosclerotic heart disease. Atherosclerotic heart disease
Conditions
Interventions
Intervention 1: After induction of anesthesia and before skin incision, remote ischemic preconditioning will perform by 3 cycles of 5-minute inflation of an upper thigh tourniquet to 200mmHg (or at le
Treatment - Devices
Placebo
After induction of anesthesia and before skin incision, remote ischemic preconditioning will perform by 3 cycles of 5-minute inflation of an upper thigh tourniquet to 200mmHg (or at least to a pressur
After induction of anesthesia and before skin incision, the tourniquet will place on the upper thigh and left uninflated for 30 min.
Sponsors
Vice chancellor for research of Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria: non-emergency on-pump first time CABG; EF higher than 35% Exclusion criteria: under 18 years of age; CABG with valve surgery; pregnancy; advanced liver disease (INR >2.0); severe renal impairment (Creatinine clearance <50 ml/min); respiratory failure (O2 Sat <90 %); acute myocardial infarction up to 14 days before surgery; advanced peripheral vascular disease affecting the lower limbs; drug therapy with sulfonamide or Nicorandil.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Acute kidney injury. Timepoint: preoperatively and 6, 12, 24 and 48 h postsurgery. Method of measurement: Acute Kidney Injury Network criteria.;Serum Troponin I. Timepoint: 0 , 6 , 12 , 24, 48. Method of measurement: Laboratory kit. | — |
Secondary
| Measure | Time frame |
|---|---|
| Atrial fibrilation. Timepoint: After surgery. Method of measurement: Data collecting form.;Dialysis. Timepoint: Before and 6, 12, 24 and 48 hours after surgery. Method of measurement: Data collecting form.;Serum creatinine. Timepoint: Before and 6, 12, 24 and 48 hours after surgery. Method of measurement: laboratory kit.;Serum CRP. Timepoint: Before and 6, 12, 24 and 48 hours after surgery. Method of measurement: Laboratory kit.;Inotrope requirement. Timepoint: 6, 12, 24 and 48 hours after surgery. Method of measurement: Data collecting form.;Ventilator time. Timepoint: After surgery. Method of measurement: Data collecting form.;Length of ICU stay. Timepoint: After surgery. Method of measurement: Data collecting form.;In-hospital mortality. Timepoint: After surgery. Method of measurement: Data collecting form. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMojtaba Shokri
Mazandaran University of Medical Sciences
Outcome results
None listed