labour induction. Precipitate labour
Conditions
Interventions
Intervention 1: Prescription of 25 microgram of sublingual Misoprostol plus vaginal placebo every four hours up to four times. Intervention 2: Prescription of 50 microgram of vaginal Misoprostol plu
Treatment - Drugs
Prescription of 25 microgram of sublingual Misoprostol plus vaginal placebo every four hours up to four times.
Prescription of 50 microgram of vaginal Misoprostol plus sublingual placebo every four hours up to four times.
Sponsors
Vice chancellor for research -Guilan university of medical sciences
Eligibility
Sex/Gender
Female
Age
15 Years to 45 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: a) single pregnancy (between 36 to 42 weeks), b) vertex presentation, c) intact fetal membrane, d) bishop score equal or less than four e) absence of uterus spontaneous contractions f) fetal weight less than 4000gr j) normal fetal heart rate h) cephalopelvic proportion Exclusion criteria: a) sensitivity to PGs b) previous history of cesarean c) uterus wall scar d) preeclampsia or blood pressure more than 140/90 mmhg e) PROM f) vaginal bleeding
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time interval from labour induction to delivery. Timepoint: After delivery. Method of measurement: Time recording of induction beginning and delivery in Questionnaire.;Delivery type frequency. Timepoint: After delivery. Method of measurement: patient medical document.;Dose amount. Timepoint: Four hours after last prescription of Misoprostol up to delivery time. Method of measurement: Patient medical document. | — |
Secondary
| Measure | Time frame |
|---|---|
| Vaginal delivery frequency during first 12 hours. Timepoint: During 12 hours from induction beginning. Method of measurement: Patient medical document.;Vaginal delivery frequency during first 12 to 24 hours. Timepoint: During 12 to 24 hours from induction beginning. Method of measurement: Patient medical document.;Tachysystole incidence rate. Timepoint: Every 4 hours until entering in active phase. Method of measurement: Fetal heart monitoring device and recording of uterus contractions.;Hyper stimulation incidence rate. Timepoint: Every 4 hours until entering in active phase. Method of measurement: Fetal heart monitoring device and recording of uterus contractions.;Cesarean rate due to FHR disorder. Timepoint: After cesarean. Method of measurement: patient medical document.;Cesarean section rate due to delivery failure. Timepoint: After cesarean section. Method of measurement: Patient medical document.;Apgar score below 7 rate. Timepoint: After delivery. Method of measurement: Patient medical document.;Meconium discharge rate. Timepoint: By presenting 3cm or more dilatation after rupture of membrance. Method of measurement: Clinical examination or patient medical document.;NICU admission rate. Timepoint: After delivery. Method of measurement: Patient medical document.;Bishop score alteration average after 4 hours. Timepoint: After 4 hours from beginning of induction. Method of measurement: Vaginal examination. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr.Seyede Hajar Sharami
Guilan university of medical sciences
Outcome results
None listed