Cutaneous Leishmaniasis. Cutaneous Leishmaniasis
Conditions
Interventions
Intervention 1: Treatment with cryotherapy 10-20 s, until the lesion with 1 mm of its surrounding is completely infiltrated, and after 5 minutes, interalesional Glucantime injection into lesion, in si
Treatment - Other
Treatment - Drugs
Treatment with cryotherapy 10-20 s, until the lesion with 1 mm of its surrounding is completely infiltrated, and after 5 minutes, interalesional Glucantime injection into lesion, in size basis, weekly
Treatment with cryotherapy 10-20 s, until the lesion and 1 mm of its surrounding is completely infiltrated, weekly up to 8 weeks
Interalesional Gluantime injection into lesion, in size basis, until the lesion is completely infiltrated and indurated, weekly up to 8 weeks
Sponsors
Research Council of Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria: presence of cutaneous leishmaniasis less than 6 months that their disease has been approved by direct smear and stained with Giemsa or positive skin biopsy, a 3-month treatment free interval from the last treatment course. Exclusion criteria: pregnancy, lactating, receiving simultaneously any therapy during study period that has antileishmaniasis effect during 2 months ago, history of significant renal, pulmonary and cardiovascular disease.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete healing. Timepoint: For the first time 6th and 8th weeks after treatment and for the second time in follow up visit after 3 months of beginning the study. Method of measurement: Measuring the size of induration and ulcer. | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects. Timepoint: at each follow up visit. Method of measurement: Physical exam. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHadis Yousefzadeh
Research center for skin disease and cutaneous leishmaniasis
Outcome results
None listed