Cutaneous Leishmaniasis. Cutaneous leishmaniasis
Conditions
Interventions
Intervention 1: Treatment with oral azithromycin 10-12 mg/kg daily untill 10 days and then repeat during 3 consecutive periods according to the improvement basis. Intervention 2: Treatment with cryoth
Treatment - Drugs
Treatment - Other
Treatment with oral azithromycin 10-12 mg/kg daily untill 10 days and then repeat during 3 consecutive periods according to the improvement basis
Treatment with cryotherapy 10-20 s, until the lesion with 1 mm of its surrounding become fully infiltrated, weekly up to 8 weeks based on lesion size or complete lesion improvement
Sponsors
Research Council of Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
1 Years to 14 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: presence of cutaneous leishmaniasis with less than 6 months of clinical course that their disease have been approved by direct smear and stained with giemsa method or skin biopsy, age<14, a 3-month treatment free interval from the last treatment course. Exclusion criteria: pregnancy, lactating, receiving simultaneously any therapy that has antileishmaniasis effect during 2 months ago, history of significance renal, pulmonary and cardiovascular disease, sensitive to azithromycin.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete healing. Timepoint: For the first intervention, at the end of each month until 4 months and for second intervention at the end of 8th week and during follow up of patients in both studied group after 3 months of beginning of the study. Method of measurement: Measuring the size of induration and ulcer. | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects. Timepoint: At each follow up visit. Method of measurement: physical exam. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHadis Yousefzadeh
Research center for skin disease and cutaneous leishmaniasis
Outcome results
None listed