Acute childhood seizure. Epilepsy
Conditions
Interventions
Intervention 1: Intervention group1: after establishing an intravenous route diazepam is infused 0.2-0.3 mg/kg to control seizure. Intervention 2: Intervention group2: buccal midazolam is administer
Treatment - Drugs
Intervention group1: after establishing an intravenous route diazepam is infused 0.2-0.3 mg/kg to control seizure
Intervention group2: buccal midazolam is administered to children with convulsion based upon the age as follow: 2.5 mg for children aged 6-12 months 5mg for children 1-4 years 7.5 mg for children5-9 y
Sponsors
Pediatric Neurology Research Center
Eligibility
Sex/Gender
All
Age
No minimum to 14 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: all children aged 6 months to 14 years old presenting with acute generalized seizure in emergency ward or pediatric neurology ward are randomly assigned to receive buccal midazolam or intravenous diazepam. Exclusion criteria: seizures due to head trauma or known metabolic causes (hypoglycemia, hypocalcemia)
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time it takes to control seizure. Timepoint: The time it takes to control seizure is measured once after using IV diazepam vs. buccal midazolam. Method of measurement: Time measured in minute, evaluated from start to the end of seizure. | — |
Secondary
| Measure | Time frame |
|---|---|
| Potential side effects. Timepoint: Potential side effects of the two drugs. Method of measurement: Clinical evaluation of possible side effect. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Seyed Hassan Tonekaboni
Pediatric Neurology Research Center
Outcome results
None listed