oral lesions in pemphigus. Pemphigus
Conditions
Interventions
Intervention 1: Intervention group: honey mouthwash 12.5%, daily, half an hour after each meal. Intervention 2: Control group: H2O2 mouthwash 1.5%, daily, half an hour after each meal.
Treatment - Other
Intervention group: honey mouthwash 12.5%, daily, half an hour after each meal
Control group: H2O2 mouthwash 1.5%, daily, half an hour after each meal
Sponsors
Private
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria: patients with oral pemphigus lesions (grades of 1-3 were considered as oral ulcers), treated with classical pemphigus (a corticosteroid and immunosuppressive). Exclusion criteria: any broad spectrum antibiotics in the patient medication instructions, underlying disease (diabetes, infections, mouth and teeth), history of allergy to honey, history of chemotherapy and radiation therapy for head and neck and lesions worsening during using honey mouthwash (in this case, treatment will be returned to the routine).
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Grade of oral lesions. Timepoint: at the begining and then every other day for ten days. Method of measurement: Oral Mucositis Visual Assessment Guide of WHO. | — |
Secondary
| Measure | Time frame |
|---|---|
| Healing erythema. Timepoint: every other day/and till 10 day. Method of measurement: Oral Mucositis Visual Assessment Guide of WHO.;Reducing pain in oral lesions. Timepoint: every other day/and till 10 day. Method of measurement: visual analog scale of pain intensity.;Improvement patient’s dietary intake. Timepoint: every other day/and till 10 day. Method of measurement: Oral Mucositis Visual Assessment Guide of WHO. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Tahere Ashktorab
Shahid Beheshti University of Medical Sciences
Outcome results
None listed