comparing effects of different doses of Misoprostol in induction of second trimester abortion.

comparing the effects of multiple doses of Misoprostol with single dose of Misoprostol plus oxitocin in induction of second trimester abortion.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT138902053797N1

Enrollment

120

Registered

2010-06-12

Start date

2009-05-10

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pregnancy and maternal care. Maternal care for known or suspected fetal abnormality and damage

Interventions

Intervention 1: Vaginal Misoprostol 600 mic and after 4 hours induction was started by high dose Oxytocin, in a way that 50 units Oxytocin was added to ringer serum 500cc and infused within 3 hours th

Treatment - Drugs

Vaginal Misoprostol 600 mic and after 4 hours induction was started by high dose Oxytocin, in a way that 50 units Oxytocin was added to ringer serum 500cc and infused within 3 hours then patient was r

Vaginal Misoprostol 600 mic., repeated every 4 hours as 400 mic until 6 doses were completed or complete abortion happened

Eligibility

Sex/Gender

Female

Age

18 Years to 42 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: pregnant women with gestational age of 14-24 weeks who were candidate for terminating pregnancy due to fetal reasons Exclusion criteria: History of allergy, having IUD, severe anemia, taking anticoagulative drugs, active liver disease, and cardiovascular disease or taking corticosteroids, history of cesarean section or abortion due to maternal reasons

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Labor to delivery time. Timepoint: duration from adminestrating drugs till abortion/delivery. Method of measurement: measuring the time, minuets.	—

Secondary

Measure	Time frame
Bleeding. Timepoint: from begining till delivery. Method of measurement: amount of blood loss.;Fever. Timepoint: from injecting drugs till abortion or delivery. Method of measurement: rate of fever.;Needs to hystrectomy. Timepoint: from injecting drugs till abortion or delivery. Method of measurement: Rate of hysterectomy.;Vomiting. Timepoint: from injecting the drugs till abortion or delivery. Method of measurement: rate of vomiting.	—

Measure

Time frame

Bleeding. Timepoint: from begining till delivery. Method of measurement: amount of blood loss.;Fever. Timepoint: from injecting drugs till abortion or delivery. Method of measurement: rate of fever.;Needs to hystrectomy. Timepoint: from injecting drugs till abortion or delivery. Method of measurement: Rate of hysterectomy.;Vomiting. Timepoint: from injecting the drugs till abortion or delivery. Method of measurement: rate of vomiting.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Maryam Zangeneh

Kermanshah University of Medical Sciences

mzangene@kums.ac.ir+98 83 1433 4157

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026