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Effect of Allopurinol in lowering blood pressure in hemodialysis patients

Effect of treatment of hyperuricemia on lowering blood pressure in hemodialysis patients: single-blind, two-period randomized cross-over study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT138902043325N2
Enrollment
55
Registered
2010-04-24
Start date
2009-04-24
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Hypertension. Condition 2: Hyperuricemia. Hypertensive renal disease, Hypertensive heart and renal disease , Secondary hypertension Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease Asymptomatic hyperuricaemia

Interventions

Intervention 1: No intervention. Intervention 2: Allopurinol a tablet (100 mg)/day,for 3 months.
Treatment - Drugs
No intervention
Allopurinol a tablet (100 mg)/day,for 3 months

Sponsors

Zanjan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Inclusion criteria: having high level of serum uric acid (serum uric acid level greater than 6.5 mg/dl (men) or greater than 5.5 mg/dl (women). This definition was based on analyses from the Atherosclerosis Risk in Communities (ARIC) Study; Exclusion criteria: uric acid level of serum less than 6.5 for men and less than 5.5 for women, known history of allopurinol hypersensitivity or those who already were on allopurinol

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Blood pressure. Timepoint: Baseline, at the beginning of each phase, each week for 3 month during each phase. Method of measurement: sphygmomanometer.

Secondary

MeasureTime frame
Blood level of uric acid. Timepoint: at the begining of study and after 3 months. Method of measurement: laboratory techniques.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Mirzamohammadi

Zanjan University of Medical Sciences

fateme_mm@yahoo.co.uk+98 24 1426 6934

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026