Effects of alpha lipoic acid supplementation on some antioxidant defence system indices in patients with chronic renal failure undergoing hemodialysis.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT138902041197N4

Enrollment

Registered

2010-11-20

Start date

2010-01-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic renal failure undergoing hemodialysis. End-stage renal disease

Interventions

Intervention 1: Daily consumption of alpha lipoic acid capsule (600 mg) for 8 weeks. Intervention 2: Daily consumption of placebo for 8 weeks.

Treatment - Drugs

Placebo

Daily consumption of alpha lipoic acid capsule (600 mg) for 8 weeks

Daily consumption of placebo for 8 weeks

Eligibility

Sex/Gender

All

Age

20 Years to 100 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: obtaining informed consent, being on HD for more than 6 months receiving 3 dialysis in week Exclusion criteria: hepatitis and other infections, age less than 20 years, receiving any NSAID and SAID, alpha lipoic acid supplement, vitamin C , vitamin E, valproic acid in the last month, gastrointestinal disorders, candidate for kidney displacement, pregnancy, lactation, smoking, presence of any side effect

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
SOD. Timepoint: baseline and after 8 weeks. Method of measurement: Specrophotometery.;GPx. Timepoint: baseline and after 8 weeks. Method of measurement: Specrophotometery.;Catalase. Timepoint: baseline and after 8 weeks. Method of measurement: Specrophotometery.;Hb. Timepoint: baseline and after 8 weeks. Method of measurement: Specrophotometery.	—

Secondary

Measure	Time frame
Health benefits for patients. Timepoint: baseline and weekly monitoring. Method of measurement: observation and evaluation of biochemical parameters.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactReza Mahdavi

Tabriz University Of Medical Sciences

mahdavir@tbzmed.ac.ir t.khabbazi@gmail.com+98 41 1335 7580

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026