Anesthesia.
Conditions
Interventions
Intervention 1: Magnesium, sulfate 50 mg/kg/10min, before induction of anesthesia and 8 mg/kg/h, intravenously throughout the surgery. Intervention 2: Normal saline, 0.2 milliliter/kg/10min, IV, befor
Treatment - Drugs
Placebo
Magnesium, sulfate 50 mg/kg/10min, before induction of anesthesia and 8 mg/kg/h, intravenously throughout the surgery
Normal saline, 0.2 milliliter/kg/10min, IV, before induction of anesthesia and then 0.1 milliliter /kg/h throughout the surgery
Sponsors
Tehran University of Medical Sciences and Health Services
Eligibility
Sex/Gender
All
Age
25 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: ASA class 1 and 2, scheduled for spine surgery Exclusion criteria: age>75, receiving sedatives, Antipsychotic, Calcium channel blocker drugs, Addicts to opium, Sensitive to magnesium and Hypertensive patients (more than 145/110)
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heart rate. Timepoint: Permanent, but recoding is every 20 minutes during 1st hour then every hour. Method of measurement: By operating room monitoring instrument: BiOSYS company.;Blood pressure. Timepoint: Every 20 minutes during 1st hour then every hour. Method of measurement: Non invasive blood pressure monitoring instrument: BiOSYS company.;Muscle relaxation. Timepoint: Every 20 minutes during 1st hour then every hour. Method of measurement: peripheral nerve stimulator (model Innervator252 HEALTHCARE -Constant Current-). | — |
Secondary
| Measure | Time frame |
|---|---|
| Consumed Opium. Timepoint: During operation. Method of measurement: Microgram opium.;Pulse oximetry. Timepoint: Permanent. Method of measurement: pulse oximetry monitoring instrument: BiOSYS company. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFarsad Imani
Tehran University of Medical Sciences and Health Services
Outcome results
None listed