A comparison of the 2 methods for the treatment of preterm labor

A comparison between therapeutic effect of Indomethacin and Nifedipin for the treatment of preterm labor in patients referring to Akbarabadi Teaching Hospital; A randomized clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT138901312624N5

Enrollment

Registered

2010-04-20

Start date

2010-06-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preterm labour. Preterm labour

Interventions

Intervention 1: Nifedipin: 10mg (one capsule) sublingually every 20 minutes for four doses. If the contractions are inhibited, Nifedipin will be continued orally (20 mg) every 6 hours for the first 24

Treatment - Drugs

Nifedipin: 10mg (one capsule) sublingually every 20 minutes for four doses. If the contractions are inhibited, Nifedipin will be continued orally (20 mg) every 6 hours for the first 24 hours, and then

Indometacine: the initial dose of 100 mg (one suppository) rectally and if the contractions continue, the same dose will be repeated 1 hour later. The maximum daily dose of Indometacine is 200 mg/day

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Inclusion criteria: pregnant women with a gestational age of 22-33 weeks (according to a reliable last menstrual period (LMP) and sonography of the first trimester), who had been admitted in the hospital for preterm labor (PTL), no rupture of membrane, singleton fetus, and being Iranian. Exclusion criteria: Any systemic disorders, being smoker, history of any drug use during pregnancy except for necessary supplements, active phase of labor ( cervical dilatation more than 5 cm and effacement of more than 50%), any vaginal bleeding, polyhydramnios, fetal anomalies or signs or symptoms of fetal death or fetal distress, intrauterine infection , Intra uterine growth restriction (IUGR), previous tocolytic therapy during present pregnancy and the women in whom continuation of pregnancy is risky like special medical problems.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Inhibiting of uterine contractions. Timepoint: 2 hours. Method of measurement: Tocography.	—

Secondary

Measure	Time frame
To delay delivery for more than 48 hours. Timepoint: 48 hours. Method of measurement: no delivery.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Maryam Kashanian

Iran University of Medical Sciences

maryamkashanian@yahoo.com+98 21 5563 3244

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026