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To reduce bleeding after bypass heart surgery

Topical Tranexamic acid will reduce mediastinal bleeding after first time CABG

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT138901243646N2
Enrollment
80
Registered
2012-03-01
Start date
2010-05-01
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischemic heart disease. Coronary artery artheriosclerosis

Interventions

Intervention 1: Washing pericardial cavity after CABG with Tranexamic acid diluted in 500 cc of saline in intervension group. Intervention 2: Washing pericardial cavity with500cc of normal saline in c
Treatment - Drugs
Placebo
Washing pericardial cavity after CABG with Tranexamic acid diluted in 500 cc of saline in intervension group
Washing pericardial cavity with500cc of normal saline in control group

Sponsors

Mazandran University of Medical Sciences Research Council
Lead Sponsor

Eligibility

Sex/Gender
All
Age
1 Years to 75 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: first time elective CABG and ejection Fraction > 35%. Exclusion criteria: age >75 years; progressive liver, kidney, lung, peripheral vascular diseases; MI within 6 weeks before surgery; NYHA 3&4; CABG with valvular surgery; insulin dependent diabetes and anticoagulant usage within 5 days before surgery.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Mediastinal drais bleeding after CABG. Timepoint: 24 houres. Method of measurement: Measuring mediastinal drainage into the chest bottle.

Secondary

MeasureTime frame
Blood and blood products transfusion after CABG. Timepoint: 24 hours. Method of measurement: Measuring units of blood and blood products tranfused during and after CABG.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Mahmoud Nouraei

Mazandaran Heart Center

smnouraei@yahoo.co.uk+98 15 1222 6161

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026