Manic episode of bipolar disorder. Bipolar affective disorder, current episode manic without psychotic symptoms, Bipolar affective disorder, current episode manic with psychotic symptoms
Conditions
Interventions
Intervention 1: discontinuation of sudium valproate. Intervention 2: continuation of sudium valproate.
Treatment - Drugs
discontinuation of sudium valproate
continuation of sudium valproate
Sponsors
Research center for behavioral disorders and substance abuse, Hamadan University of Medical Science
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: obtaining informed consent, Diagnosis of bipolar I disorder, manic episode, must be confirmed according to DSM IV-TR criteria, Manic episode refractory to pharmacotherapy, receiving therapeutic doses of valproate before ECT for at least 5 days, Serum levels of valproate =50 µg/ml, Administration of ECT by attending psychiatrist, age 18-60 years Exclusion criteria: Uncontrolled physical condition, Pregnant and nursing women, LFT: 3 fold greater than upper normal limits, receiving other anticonvulsant medications, History of epilepsy
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement rate of mania. Timepoint: after second, fourth, sixth and at the end of sessions of ECT. Method of measurement: CGI and YMRS. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactGholamreza Bigdelo
Research center for behavioral disorders and substance abuse, Hamadan university of medical sciences
Outcome results
None listed