Effect of pentoxifylline on urinary protein excretion reduction in diabetic nephropathy patients.

A survey of additive antiproteinuric effect of pentoxifylline on diabetic nephropathy patients with proteinuria taking losartan and enalapril.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT138901013596N1

Enrollment

100

Registered

2010-05-20

Start date

2009-08-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Non-insulin-dependent diabetes mellitust. Condition 2: Diabetic Nephropathy. Non-insulin-dependent diabetes mellitus Glomerular disorders in diabetes mellitus

Interventions

Intervention 1: intervention:4oo mg pentoxifyllin daily + enalapril + losartan. Intervention 2: Control:enalapril+losartan.

Treatment - Drugs

intervention:4oo mg pentoxifyllin daily + enalapril + losartan.

Control:enalapril+losartan

Eligibility

Sex/Gender

All

Age

25 Years to No maximum

Inclusion criteria

Inclusion criteria: inclusion: diabetic nephropathy with GFR more than 30 ml/min and proteinuria more than 150 mg/24h. exclusion: pentoxifylline sensivity, congestion heart failur, uncontroled HTN, patients that recived new drug with antiprotein effect( non dihydropridine calcium channel blockers, sprinolacton,beta blockers, diuretics) during study.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Proteinuria in diabets patients. Timepoint: 3 & 6 month later. Method of measurement: measure of protein in 24h urin collection by using colorimetry.	—

Secondary

Measure	Time frame
Pentoxifylline complications. Timepoint: monthly. Method of measurement: checklist & phisical exam.;Measure of GFR. Timepoint: monthly. Method of measurement: Cockcroft- Gault.;Measure of serum potasium. Timepoint: monthly. Method of measurement: flame photometry.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Elena Lak

Ahvaz Jundishapur University

elenalak@ajums.ac.ir+98 916 311 4138

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026